Medicinal chemistry of Annonaceous acetogenins: design, synthesis, and biological evaluation of novel analogues.
نویسندگان
چکیده
Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an alpha,beta-unsaturated gamma-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues.
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ورودعنوان ژورنال:
- Molecules
دوره 14 9 شماره
صفحات -
تاریخ انتشار 2009